Opportunities for youth can be severely limited among many communities in the Middle East and North Africa (MENA) region that are disrupted by conflict or impoverishment. Recent political and economic factors, as well as a rapidly growing youth population, have greatly increased the vulnerability of at-risk youth in the MENA region. This HHI study utilized a multi-method approach -- including systematic reviews of the peer-reviewed and gray literatures, stakeholder analyses, and in-region discussions with youth and stakeholders -- to identify the current needs, activities, stakeholders, and opportunities related to at-risk youth in the MENA region. It is our hope that this initial report and its recommendations will be a starting point of discussion and collaboration as we develop a cross-disciplinary, cross-institutional Middle East Youth in Crisis Project based at the Harvard Humanitarian Initiative.